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Allgens Medical is driven to provide to clinicians and patients the best in class synthetic bioactive bone graft products. All our products are carefully and visionarily designed for superior handling properties, revascularization-enabling characteristics and physiologically degradation resembles the natural degradation rate for quicker patient recovery time. Allgens Medical is proud for its strong technical staff of many talents Ph.Ds and MSs in biomedical disciplines with many years experience working with physicians to invent next generation medical devices. If you are interested in potential collaborations please inquire by phone or email at info@allgensmed.com
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What is the difference between bone autograft, allograft and synthetic bone graft?

Autograft is bone harvested from the same patient the graft will be used on. A typical site for autograft harvesting is the hip. Autograft harvesting increases surgery time, creates a second operative site, and can cause complications and morbidity.

Allograft is bone procured from another individual of the same species. The healing growth factors are all the same as the patient’s own bone. Allografts are provided by tissue banks.

Synthetic Bone Graft is bio-mimetically synthesized bone graft. Components are naturally present in native bone, minimizing likelihood of disease transmission and contamination. Synthetic bone graft has been successfully used by orthopedic and oral surgeons in human medicine for decades.

What are osteoconductive and osteoinductive?

Osteoconductive refers to a graft’s property of providing scaffolding for bone to grow onto. Osteofil™ and DenOss™ from Frienimal Implants is osteoconductive, because it contains osteoconductive cancellous bone chips. This scaffolding provides attractive surfaces for new bone cells (osteoblasts) to migrate in on.

Osteoinductive refers to a graft’s property of having growth factors that attract osteoblasts. Osteofil™ and DenOss™ from Frienimal Implants is osteoinductive, because it contains Collagen component that has been proved to attract osteoblasts to the surgical site.

Why should I use bone graft in orthopedics?

Filling voids with bone graft accelerates the healing process in fracture repairs, spinal fusions, because bone graft provides scaffold for host bone to grow onto (osteoconductivity) and actively attracting osteoblasts (osteoinductivity). Accelerated healing not only allows the patient to return to full function sooner, it also increases the chances of a successful outcome of your surgical procedures.

Even when there are no voids after realigning a fracture, the usage of bone graft accelerates healing because it increases surface area for bone to grow on and more osteoblasts are recruited to site.

Why is bone graft used in dentistry?

Bone graft is used to reverse bone loss caused by periodontal disease or due to tooth extraction. Applying bone graft can result in reversal of the disease process, reducing the probing depth, clinical attachment gain, clinical repair of lost bone, and histologic reconstruction of the attachment apparatus. Teeth that normally need to be extracted can be saved with Ossifil™ from Allgens Medical, LLC.

Bone graft is also used for filling extraction sites after tooth extractions. Because animal teeth have much longer roots than human teeth, extractions leave much deeper voids behind.

  • Filling extraction sites with bone graft leads to strong and fast reconstruction of natural, healthy bone tissue in these deep extraction sites.

  • This prevents bacteria from settling in, which improves oral health and overall patient health.

  • Reconstructing bone after tooth extractions also prevents fractures of the mandible – a risk that is considerable as there is often only little bone left after an extraction.

What are the advantages of using Synthetic Bone Graft vs. autograft?

  • Not having to procure autograft reduces your surgery time and cost.

  • You avoid the potential morbidity associated with autograft procurement. It’s documented that the morbidity rate associated with the collection of bone autograft is over 25%.

Studies show that Synthetic Bone Grafts, in combination use with autograft or in combination use with bone marrow, are as effective as autograft in bone healing. While autograft has the advantage of being osteogenic, Premixing Synthetic bone graft with patients’ blood (bone marrow) allowing for immediate access to growth factors. This offsets the advantage of osteogenicity and helps to make synthetic bone graft as effective as autograft in long-term studies.

Because synthetic bone graft is as effective as autograft and makes graft harvest unnecessary, it is becoming the grafting option of choice.

What are the advantages of Synthetic Bone Graft vs. Allograft?

Bio-mimetically synthesized bone graft with components are naturally present in native bone, such as Bongold TM, minimizing likelihood of disease transmission and contamination associated with Allograft.

What are the different types of Bongold™?

There is Bongold™ for orthopedic applications and Ossifil™ for periodontal applications. Bongold™ comes in “Powder”, “Particles”, “Blocks”, “foam” and “cylinders”. All consist of the same collagen and hydroxyapatite components and a osteoconductive porous scaffold. Please refer to product brochure for details.

What are the applications for Bongold™ and Ossifil™ ?

Bongold™ is used for orthopedic applications as a filler for gaps and voids that are not intrinsic to the stability of the bony structure.

Ossifil™ is used for tooth extractions, furcation defects, horizontal and vertical bone loss, fracture of the mandible, and any other void filling or bone augmentation procedure that requires grafting.

What is the shelf life of our bone graft?

Bongold™ and Ossifil™ and can be stored at room temperature for 4 years.

What do I do with expired bone graft?

Expired graft should be discarded as you would any other expired surgical supply. It is not considered a biohazard. We recommend that you mark on the package to indicate that it is expired or not suitable for transplant.

How do I use Bongold™ and Ossifil™?

Bongold™ and Ossifil TM is used in much the same manner as autograft. It works best when mixed with patient blood or marrow. Blood and marrow contain the progenitor cells that can respond to the native growth factors (BMPs) in our bone graft matrix. These cells initiate new bone formation.

The product is packed in a sterile pouch, with package insert, all packed in a box. Some forms are packed in glass vials in a sterile pouch. The sterile pouch package can be peeled open by a Technician and contents dropped onto the sterile field.

Bongold™and OssifilTM: Powders can be applied to the bony defect by creating a granular paste or by pouring the dry powder directly into a blood filled site.

To create a paste, mix it preferably with patient’s blood, or with sterile saline. Then gently pack the paste or material into the surgical defect site with a spatula or simply by hand.

Bongold™and OssfilTM: Particles can be applied by pouring the dry particles to the blood filled site directly.

Bongold™and OssifilTM: Plug/Membrane/blocks/Cylinders are preferably mixed with patient’s blood or with sterile saline to moisten uniformly. Then place the moistened materials in the site gently (do not press). Bone graft should fill the defect and be in contact with viable bone as much as possible. Don’t blot away the blood/moisture at the site as the blood contains the cells and growth factors necessary to assist in bone healing.